منابع مشابه
Adipose Tissue Glycogen Synthetase
In vitro activation of adipose tissue glycogen synthetase caused a change in kinetic properties of the enzyme. The nonactivated enzyme had a K, for UDP-glucose of 2 m when measured without glucose-6-P. The K, decreased to 0.7 mM in the presence of 2 mM glucose-6-P. The K, for UDP-glucose of the activated enzyme was 0.8 mM. Glucose-6-P affected both the K, for UDP-glucose and the v m&x of the no...
متن کاملEnhanced glycogen metabolism in adipose tissue decreases triglyceride mobilization.
Adipose tissue is a primary site for lipid storage containing trace amounts of glycogen. However, refeeding after a prolonged partial fast produces a marked transient spike in adipose glycogen, which dissipates in coordination with the initiation of lipid resynthesis. To further study the potential interplay between glycogen and lipid metabolism in adipose tissue, the aP2-PTG transgenic mouse l...
متن کاملEnzymes concerned in the synthesis of glycogen from glucose in the brown adipose tissue.
Under normal conditions glycogen cannot be detected in adipose tissue. When animals are first starved and then fed on a carbohydrate diet, glycogen appears temporarily in this tissue (see Hausberger & Neuenschwander-Lemmer, 1939). Tuerkischer & Wertheimer (1942) investigated the phenomenon in detail and found that, in the rat, this deposition of glycogen was particularly marked in the brown adi...
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This study investigates the consequences of inhibition of adipose tissue lipolysis on skeletal muscle substrate use. Ten subjects were studied at rest and during exercise and subsequent recovery under normal, fasting conditions (control trial, CON) and following administration of a nicotinic acid analog (low plasma free fatty acid trial, LFA). Continuous [U-13C]palmitate and [6,6-2H2]glucose in...
متن کاملRefeeding-Induced Brown Adipose Tissue Glycogen Hyper-Accumulation in Mice Is Mediated by Insulin and Catecholamines
Brown adipose tissue (BAT) generates heat during adaptive thermogenesis through a combination of oxidative metabolism and uncoupling protein 1-mediated electron transport chain uncoupling, using both free-fatty acids and glucose as substrate. Previous rat-based work in 1942 showed that prolonged partial fasting followed by refeeding led to a dramatic, transient increase in glycogen stores in mu...
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ژورنال
عنوان ژورنال: The Journal of Physiology
سال: 1945
ISSN: 0022-3751
DOI: 10.1113/jphysiol.1945.sp004084